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Preventing Glutathione Depletion Even though your body produces its own glutathione, many factors can deplete your available stores, leaving your cells vulnerable to damage from oxidative stress, free radicals, and cancers

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Numerous conditions can alter the level of GSH synthesis via changes in glutamate-cysteine ligase activity and expression of the GCLC gene such as oxidative stress, antioxidant levels, hormones, cell proliferation, and diabetes mellitus