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L-arginine and L-citrulline supplementation in pregnancy: A systematic review
This work was partially supported by the National Natural Science Foundation of China 82273961 (M.-W.W.), 82073904 (M.-W.W.) and 81872915 (M.-W.W.)
It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
It has a long history of use in wound healing and skincare with an excellent safety record being nontoxic and effective at very low concentrations
Typically, health insurers do not provide coverage for these medications, particularly when prescribed off-label for conditions such as SUD that currently lack FDA approval (National Association of Insurance Commissioners, 2024)
Elevated list prices could restrict early access and overburden health systems, as cost becomes a salient concern for patients and providers alike
