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Group II (mGluR2 and mGluR3) and group III (mGluR4, mGluR6, mGluR7, and mGluR8) are predominantly coupled to Gi/o proteins, whose activation inhibits adenylyl cyclase [31, 32]

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It is verified that GAS can reduce the levels of pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), while increasing the level of anti-inflammatory cytokine interleukin-10 (IL-10) [31]

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Among these candidates, miR-29b-3p and miR-769-5p showed significantly altered expression in HCC and PCa tissues compared with adjacent non-tumor tissues (Fig