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For instance, interferon- (IFN-) released by cytotoxic T cells (CTLs) activates the downstream JAK-STAT1 signaling pathway, downregulating the expression of the cystine/glutamate antiporter system (xc system), thereby reducing intracellular GSH synthesis, increasing free iron levels, and ultimately inducing ferroptosis in GBM cells [91]

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doi: 10.1007/s40264-020-00953-0 46 MukhtarI.AnwarH.HussainG.RasulA.NaqviS

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species