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Third, consider your study's endpoint

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Alternatively, perhaps sites of ER-mitochondrial contact facilitate spatially restricted exchange of glutathione as they do for other metabolites such as calcium and reactive oxygen species (Joseph, Booth, Young, & Hajnoczky, 2019)

Experimental data indicate increased functional tone of the lower esophageal and pyloric sphincters following peptide administration, a response associated with reduced reflux-related injury and attenuation of esophageal inflammation in animal models (11)