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The GSSG-dependent oxidation of roGFP2 by fused PfGrx variants is two to three orders of magnitude faster than the oxidation by unfused PfGrx(SSG) variants and more than seven orders of magnitude faster than the uncatalyzed reaction with GSSG (Table 1)

Another investigation found that hepatoma-derived growth factor (HDGF), secreted from activated Mller cells, enhances microglial polarization toward a pro-inflammatory M1 phenotype via Dectin-1 signaling, worsening cytokine storms and BRB disruption in early NPDR (53, 54)

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For generation of the CPZ and LPC snRNAseq datasets, animal procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of the Childrens National Hospital (protocol #30578)

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