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Around 70% of American adults are obese or overweight, and they have an increased risk of premature death and a variety of health problems, including heart attack and stroke

Jung, G

INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours

The FDA labels for weight management formulations explicitly recommend comprehensive lifestyle intervention as part of treatment

Semaglutide is indicated, in combination with a reduced calorie diet and increased physical activity, to reduce excess body weight and maintain weight reduction long term in adults and pediatric patients aged 12 and older with obesity, and in adults with overweight plus at least one weight-related comorbid condition

Author contributions JM-M: conceptualization, data curation writing-original draft and writing-review & editing