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Competitive Inhibition and VMAT Reverse Transport : Amphetamines are also recognized as substrates by VMAT2 and actively compete with endogenous dopamine for vesicular uptake, further inhibiting normal dopamine storage (Wimalasena 2011)
Do not use PT-141 Nasal Spray if you: Precautions: This information is for educational purposes and not intended to diagnose, treat, or cure any disease
What exists is a strong pre-clinical foundation in rodents, a biologically plausible rationale for studying similar effects in dogs, and a clinical patient population that presents with the exact disease categories the rodent literature has focused on