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Kidney Problems Some GLP-1 drugs have been linked to kidney issues, including: Acute kidney injury Worsening of chronic kidney disease Patients with pre-existing kidney conditions should be closely monitored while on GLP-1 therapy
Personalized adjustments are often needed based on individual health status and goals
The drug is already creating a significant deficit
Also nicknamed twincretin, tirzepatide is a dual GIP/GLP-1 receptor agonist (GLP-1 RA) that works by activating the GIP and GLP-1 receptors, enhancing insulin secretion in response to glucose intake, decreasing glucagon levels, improving insulin sensitivity, decreasing food intake, and slowing gastric emptying
The peptide inhibited hyperglycemia-induced epithelial-mesenchymal transition (EMT) and downregulated fibrosis-related genes, preventing the subretinal fibrosis that represents end-stage proliferative diabetic retinopathy
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