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Eating breakfast within an hour of waking naturally triggers bowel activity through the gastrocolic reflex

For some, it works best at the first sign of symptoms

We could also consider a randomized study of patients who have failed bariatric surgery between a second surgery group and a drug treatment group, Avignon said

Patients experiencing difficulties affording or accessing timely prescriptions should contact their GP surgery or diabetes specialist nurse rather than extending medication use beyond safe limits

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Nature 575:688692 Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, Yang X, Fei J et al (2021) Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells