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I have had patients with a history of Lyme disease who have flared up after contracting COVID-19

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The shelf life of the original lyophilised powder is similarly defined by the manufacturer's data and SmPC

doi: 10.3390/ijms23042144 6 LiuYGuRGaoMWeiYShiYWangXet al

Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis