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GSH deficiency results in the activation of von Willebrand Factor (Ibrahim et al., 2004) and in the accumulation of ROS, which affect clotting and platelet activation, impair endothelial function, and predispose to the risk of thrombotic events (Violi et al., 2017): notably, hypercoagulation is a prominent life-threatening complication in COVID-19 patients (Giardini et al., 2020)

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Eng, who worked for many years at the Bronx VA medical center, was awarded a 2013 Golden Goose award, a prize meant to honor federally-funded research that leads to major biomedical breakthroughs

As of early 2025, the FDA had also received hundreds of adverse event reports linked to compounded semaglutide and compounded tirzepatide, many involving dosing errors from self-administration of multidose vials