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Clin Cancer Res

Soft tissue sarcomas or metastases from other cancers can also produce masses beneath the skin

In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions

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Its the microscopic rust of modern life: pollution, processed food, poor sleep, blue-light overstimulation