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In short, GLP-1 does everything a diabetes drug should do

In your body, the GLP-1 hormone helps release insulina hormone that helps move glucose (sugar) from the blood into other areas of the body, where it can be used for energy

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Delayed gastric emptying and gastrointestinal symptoms can worsen diet quality GLP-1 receptor agonists are also associated with delayed gastric emptying and can cause nausea, vomiting, early fullness, and food aversions

These two characteristics make it inherently unsuitable for standard topical delivery: it degrades before it absorbs, and it repels the lipid-rich skin barrier