DOI: Published online: October 15, 2025 1 Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan 3 Kurinami Clinic, Kanzaki, Kumamoto, Japan 4 Division of Cardiovascular Medicine, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan 5 Division of Preventive Cardiology, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan Corresponding author: Hideaki Jinnouchi
Tapia, E
By binding to regional receptors in the gastrointestinal tract, GLP-1s alter gut motility in different areas of your intestines, affecting the physical contractions which push food (and waste) through your body
For gut-targeted indications, it may be the superior route because high local concentrations in the GI tract are exactly what you want
Is it safe to take GLP-1 continuously for years
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