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GLP-1 receptor agonists are authorised for the treatment of diabetes 1 or for weight management under certain conditions 2 or both 3

Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration

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for example, a phase 2 randomized trial demonstrated that once-weekly administration of semaglutide reduced alcohol craving and consumption in adults with alcohol use disorder [92], and meta-analytic data suggest improvements in emotional well-being and quality of life among individuals receiving GLP-1-based therapy [93]

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