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patients hospitalized with COVID-19 were overweight or had obesity

In mouse models of cecal ligation and puncture (CLP)-induced sepsis, plasma-derived EVs affected RBC deformability, increasing RBC rigidity [387]

Furthermore, another secondary analysis of the STEP-HFpEF and STEP-HFpEF DM trials showed that semaglutide reduced C-reactive protein levels and improved symptoms, physical limitations, and exercise function in HFpEF obese patients [84]

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It is commonly used in research involving metabolic signaling, incretin receptor biology, multi-hormone pathway activity, and endocrine system regulation

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