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Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition

Initially, shots might be given more frequently to establish adequate levels, but over time, maintenance doses can be spaced out to once every few months

Ann Clin Lab Sci, 45 (4), 426-432