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Two classes of additive are outright incompatible
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J Cell Mol Med (2011) 15(4):74755
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CuAAC involves the use of copper (Cu(I)) catalysts to enhance the reaction rate and regioselectivity toward the 1,4-substituted ring, avoiding the generation of a mixture of regioisomers that could affect the chemical and biological properties of the heterocycle (Du et al., 2021)
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