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In a model of non-ischemic HF in dogs (tachycardiomyopathy induced by pacemakers), IV infusion of GLP-1 increases left ventricular (LV) contractility (LV dP/dt increased by 98%, stroke volume by 102%, and cardiac output by 57%) and decreases LV end-diastolic pressure, heart rate, and systemic vascular resistance
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There are five known subtypes of Y receptors, namely, Y1R, Y2R, Y4R, Y5R, and Y6R
Finally, the study included only male rats, which does not reflect the realm of liver fibrosis affecting both male and female rats
2026 Jan;54(1):223-229
Many patients hear that they need a certain BMI to qualify for GLP-1 weight loss treatment, but they are not always sure how BMI is actually calculated
Patients treated with SGLT2i were less likely to be diagnosed with new CKD over a 5-year period post initiation compared with the GLP-1 RA cohort (RR 0.49 [95% CI 0.28, 0.86] p =0.0118)
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