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Gu M, Jin J, Ren C et al (2020) Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-B axis and ameliorates osteoarthritis in mice
In the present study, we extend these findings by showing livers from GCLM KO mice exhibit a persistently greater level of oxidant stress as measured by protein carbonylation and expression of redox-sensitive genes
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Excess ROS then activates the NLRP3 inflammasome in microglia, promoting maturation and release of IL-1 ( 4.3 GSH metabolism: a central hub in mid-late SAE The hippocampus, with its high metabolic demands and low antioxidant capacity, is uniquely vulnerable to septic injury ( A Stat1-Gpx3 hub was identified, where TNF-/IL-1-induced Stat1 activation suppresses Nrf2 (confirmed by reduced hippocampal Nrf2)
Potential Cartilage and Joint Support: Preliminary research has suggested that AOD-9604 may possess regenerative properties related to cartilage repair and joint health, independent of its metabolic effects
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