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The patient had a history of migraines, anxiety, colon polyps, and gastroesophageal reflux disease

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Within a year, patients regain as much as two-thirds of the weight they lost

Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological glycemic variability in rats, can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress

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A key mechanism underlying this effect is the modulation of macrophage polarization