It becomes even more important for practitioners to be careful about who should and should not be prescribed these medications, said Naval Vikram, a diabetologist and professor in the department of medicine of the All India Institute of Medical Sciences in New Delhi
Novel immunotherapy combinations with chemotherapy or targeted agents/tyrosine kinase inhibitors are being assessed and developed for multiple indications that will add another layer of complexity to adverse events and their management
If fatigue is severe, persistent, or paired with fainting, confusion, chest pain, or dehydration symptoms that dont settle, get medical advice promptly rather than pushing through
69 Conversely, the extracellular release of decorin (DCN, an extracellular matrix-derived damage-associated signaling proteoglycan), 70 high mobility group box 1 (HMGB1, an architectural DNA-binding factor in the cell nucleus), 71 and nuclear receptor coactivator 4 (NCOA4, a mediator of ferritinophagy) 72,73 may function as damage-associated alarm signals that promote inflammatory responses in the local microenvironment
A study of 185,066 people with type 2 diabetes found that those taking a GLP-1 receptor agonist had a slightly higher risk of developing diabetic retinopathy but a lower likelihood of serious complications such as vision loss ( JAMA Network Open , Aug
In: NEJM: 26.06.2023,