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Genetic ablation of GLP-1Rs in alpha cells results in glucose intolerance in vivo and suppression of glucagon secretion in isolated islets at low glucose concentrations [56]
Roger L, Tomas F, Gire V
In other words, it turns on: It is glucose that makes GIP receptors work
Paus, R., Slominski, A
Another strategy is to start at a lower dose if medically appropriate, since lower doses cost less then titrate up slowly, which not only is gentler on your wallet but can minimize side effects
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