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PLoS ONE 2 , e880 (2007)

By simultaneously activating GLP-1R to boost insulin secretion and GCGR to stimulate fat oxidation, these medications outperform single-target therapies in enhancing metabolism (Boland et al., 2020)

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In a study of more than 3,000 adults with obesity, the highest dose of orforglipron resulted in an average weight loss of 27.3 pounds over 72 weeks, with a safety profile consistent with injectable GLP-1s

Primary research applications include Alzheimer's disease, vascular dementia, age-related cognitive decline, and neurological recovery after brain injury

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