Despite the pleiotropic properties of GLP-1, including its insulinotropic effect found in rats, pigs, and humans, its extremely short plasma half-life of less than 2 minutes constituted a huge brick wall in the path of GLP-1 to be developed as a glucose-lowering medication
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Alcohol adds empty calories, lowers inhibitions around eating, disrupts sleep, and can interfere with metabolic health
GLP-1 delays gastric emptying via stimulating inhibitory nitrergic myenteric neurons [18] and activating vagal afferents [19], leading to reduced gastrointestinal motility [20]
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Pancreatitis Acute pancreatitis has occurred in patients treated with GLP-1 agonists, including tirzepatide