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Therapeutic implications and future directions Currently, the available evidence demonstrates that region-specific BBB dysfunction including reduced CBF (shortfalls and dysregulations), impaired BBB integrity (increased BBB permeability and transport system), and vascular inflammation (extravasated plasma components and peri-vascular inflammatory responses) contributes to the onset and progression of multiple neurodegenerative disorders

Ex vivo electrophysiological recordings identified lateral septum as a possible target for tirzepatides neural effects Before conducting a proteomic analysis of brain tissue from the repeated tirzepatide and long- term alcohol drinking experiment, where rats were sacrificed 24 hours after their final treatment, we performed electrophysiological screening to identify which reward-related circuits (9, 49) show detectable responses to tirzepatide treatment

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