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Studies have shown that stopping the medication often leads to weight regain, since appetite signals and metabolism can return toward baseline, so your provider might discuss: Maintenance dosing: This is the dose used to help maintain your weight and prevent regain, not the higher dose used during active weight loss

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Studies suggest that animal models exposed to Ipamorelin exhibited a weight gain of approximately 17%, which may be attributed to the peptides possible impact on ghrelin receptors

Renal and systemic effects of calorie restriction in patients with type 2 diabetes with abdominal obesity: a randomized controlled trial

Under obese conditions, LEPs regulatory effects on insulin sensitivity become attenuated, contributing to insulin resistance

doi: 10.1002/ptr.6054