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Hypokalaemia (low potassium) can be clinically important, especially with vomiting/diarrhoea or low intake
In the 2021 STEP-1 trial (1,961 adults with obesity or overweight), participants receiving semaglutide plus lifestyle intervention experienced a 14.9% mean weight loss after 68 weeks, while those on placebo lost only 2.4%
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Metabolic Support: More muscle means a higher resting metabolic rate, aiding long-term fat-loss maintenance
Many research planning windows are shorter 12 to 24 weeks is common for tolerability and titration assessment, with longer cycles for efficacy endpoints
Cecum Video Endoscopic Sequence 6 of 7
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