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Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26

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1,35 It exerts its effects by inhibiting hepatic glucose production and improving insulin sensitivity

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Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M