Taking the Next Step Insulin resistance sits at the core of many metabolic problems, and addressing it can produce improvements that ripple across multiple aspects of health
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The FDAs July 2026 briefing document specifically stated that the agency did not intend to issue a final determination until it had considered the committee process and completed its reviews
Mild diarrhea is common
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Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone