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In this article, we will conclude with the potential pharmacological mechanisms of GLP-1 treatment for MASLD, including clinical insights into GLP-1RAs and co-agonist drugs

It also supports the liver's Phase II detoxification pathways, helps regulate the immune system's inflammatory response, and regenerates other antioxidants like vitamins C and E

Answer: Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that includes semaglutide (Wegovy, Ozempic, Rybelsus), tirzepatide (Zepbound, Mounjaro), liraglutide (Victoza, Saxenda), and orforglipron (Foundayo), have become increasingly popular for obesity treatment (Mehrtash, JAMA Intern Med 2025)

F., Lim, Y

Generally, most healthcare providers do not recommend taking these medications together because this combination has not been well studied in clinical trials and is not FDA-approved for safety and efficacy

Of these, 35 were preclinical animal studies and only one represented a human clinical investigation