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J Am Chem Soc, 2025, 147: 4443744446 Chen ZL, Zhu C, Zhao R, et al

Reduced kidney function and folate status are major confounders, since both can raise MMA and/or homocysteine independently of B12

Valenti L, Fracanzani AL, Dongiovanni P, et al

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Chronic kidney disease (CKD): To reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with CKD at risk of progression