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The delayed-release preparations, designed to deliver metformin to the lower small intestine, were found to be poorly absorbed, resulting in lower metformin blood levels than the other preparations

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This phenomenon is particularly relevant in intracellular environments, where host cells generate ROS as an antimicrobial defense

Following cellular uptake, however, nanomedicines are frequently sequestered in endosomes and lysosomes, where cargo degradation or entrapment can severely limit therapeutic efficacy