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Week 5 to 8: For weekly formulations, steady-state drug concentrations are achieved, and the first dose escalation typically occurs around week 4 or 5

In the present study, a mouse model of chronic oxidative stress due to compromised de novo GSH synthesis (GCLM KO) 16 exhibited unexpected protection from chronic alcohol consumption-induced hepatotoxicity and steatosis

10.2337/db16-0058 65 HayashiN.NakamoriS.HiraokaN.TsujieM.XundiX.TakanoT.et al (2004)