This indicates that the anti-inflammatory effects of EC largely depend on the integrated action of its microbial metabolites rather than the isolated activity of the parent compound itself ( 5 Limitations and future perspectives Despite its significant biological activities, EC faces major challenges in clinical application, primarily due to its low bioavailability
Front Pharmacol 14:1147414 Qi Z, Duan A, Ng K (2023) Selenoproteins in health
748 Melatonin could improve learning and memory abilities in rats with hypoxic-ischemic brain injury by regulating the AKT/Nrf2/GPX4 signaling pathway
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Other significant organs include kidneys, skin, and colon