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2 Vital role of mitochondria in AS 2.1 Mitochondrial dysfunction During AS progression, mitochondrial dysfunction is associated with progressive deleterious changes, including 1) the accumulation of mtDNA mutations, 2) excessive production of mtROS and diminished antioxidant defense, leading to increased oxidative damage, and 3) mitophagy inhibition, leading to a decline in mitochondrial renewal

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Martn-Rufin et al., 2014)

High ALP levels mean your liver is under attack

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They are best suited for those who are at or near their target weight but have specific areas of concern