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Moreover, GLP-1 receptors interact with various neurotransmitter systems such as serotonin, dopamine, and glutamate, which are essential for mood regulation and may contribute to the onset of depression and other psychological disorders [82]

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(2) SNAC molecules leave the aqueous cluster one at a time, incorporating into the membrane to form dynamic, SNAC-filled membrane defects, which allow semaglutide to bypass the barrier formed by the phospholipid head groups

doi: 10.1016/j.jff.2020.104261 77 LiuX.ZhaoF.LiuH.XieY.ZhaoD.LiC