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UKPDS 34 UKPDS 34 (N=1,704 overweight patients) compared metformin to conventional dietary therapy over a median 10.7 years
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Monitor fasting glucose and HbA1c, as GH pathway stimulation can impact insulin sensitivity
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These risks primarily involved the digestive system and included nausea and vomiting, stomach pain, heartburn and gastroparesis, or stomach paralysis
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