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The FDA has approved the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for weight loss and to reduce the risk of major adverse cardiovascular events (MACE)

The most effective GLP-1 drug for weight loss currently (as of early 2026) is tirzepatide, marketed under the names Zepbound (for weight loss) and Mounjaro (for diabetes)

Prediction #1: More Lawsuits Due to Adverse Effects The number of lawsuits against GLP-1 companies (like Novo Nordisk and Eli Lilly) has grown significantly, expanding from just 55 consolidated cases in early 2024 to more than 4,400 total cases by mid-2026 When I wrote the original piece, news outlets were reporting a few dozen lawsuits against manufacturers Novo Nordisk and Eli Lilly

Furthermore, metformin increased plasma GLP-1 levels in rats genetically lacking DPP-4 [9]