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After donating that electron, glutathione cycles between its reduced (GSH) and oxidized (GSSG) forms
Back Laughton, NB, Macallum, AB (1 June 1932) 'The Relation of duodenal mucosa to internal secretion of the pancreas', Proceedings of the Royal Society of London
Fogarty, 2019)
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Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig
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