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qRT-PCR was performed on an Applied Biosystems Step One System (Thermo Fisher Scientific) using the TB Green kit (Takara, RR420A)

Last reviewed: May 20, 2026 Last updated: May 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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all other gliptins require dose reduction or avoidance in moderate-to-severe renal impairment prescribers should consult the relevant SmPC

High), including those with ASCVD or high cardiovascular risk (Class III