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These effects contribute to renal protection and may improve cardiac function in T2D patients with cardiovascular risk
Assessment: subjective sexual responses (Female Sexual Function Index), physiological markers, side effects
Cardiovascular autonomic neuropathy, sexual dysfunction, and urinary incontinence in women with type 1 diabetes
Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect (8385)
However, more large-scale clinical trial data are needed for a clear causal relationship to be established
They are distinct research tools used in different experimental contexts depending on the receptor subtype being investigated
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