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And so it's like, okay, well they live a hundred percent longer, but they go into this weird state

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For example, increased gastric emptying time due to the mechanism of action of dulaglutide was described in the developed PBPK model by modulating the default gastric MRT

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Superimposing a tonic pharmacological brake on top of this feedback system creates competing signals, and it would be unsurprising if intestinal feedback partially normalized emptying over time even while the drug is present

Most people notice visible changes between weeks 6 and 12, though the timeline depends on starting weight, dose, and individual physiology