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Yano M et al

Remember that clinical trials failed to demonstrate statistically significant weight loss in the largest study, leading to development termination in 2007

Participants receiving AOD-9604 maintained stable blood glucose levels, showed no changes in insulin sensitivity, demonstrated no alterations in HbA1c, and exhibited no increased risk of hyperglycemia or diabetic complications

Preclinical studies have administered 5-Amino-1MQ in rodent dietary models to observe whole-body metabolic parameters, including body composition, energy expenditure, and plasma metabolite profiles