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In the present study, we established a rat model of -cell failure using LOsG and found that high glucose promoted PSC activation and proliferation to enhance pancreatic fibrosis

The charge state of every ionizable group -amino (pKa ~9), -carboxyl (pKa ~2), and each side chain is determined by the Henderson-Hasselbalch equation and the 2 rule

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However, LIRA led to a notable downregulation of Nox-1 mRNA ( p = 0.030) and a reduction in ET-1 protein expression ( p = 0.044)

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Oxidative stress occurs when harmful molecules known as free radicals outnumber the antioxidants that neutralize them