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Using a non-inferiority margin of 0.4% for PIONEER 2 and 0.3% for PIONEER 3, non-inferiority was demonstrated for all comparisons except semaglutide 3 mg versus sitagliptin 100 mg

Patients can elect to use topical anesthetic cream if they desire, although this is normally not required

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Patients can have their prescription injections done in their home by a licensed healthcare provider

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