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There is no universal endpoint, the right answer is determined in ongoing consultation with your provider

[12] The approved dosing for both indications involves subcutaneous injection once weekly, with gradual dose escalation from 2.5 mg to maintenance doses of 5 mg, 10 mg, or 15 mg based on individual response and tolerability

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Targets in the 1.2 to 1.6 grams per kilogram bodyweight range reduce muscle wasting and lower the chance of muscle weakness and soreness