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Recent work suggested that the reduction in both food intake and body weight observed in response to combined treatment with GLP-1RAs and PYY 3-36 results in synergistically-enhanced activation of discrete hypothalamic and brainstem circuits that regulate appetite, including the arcuate nucleus (ARC), the paraventricular nuclei of the hypothalamus (PVNs), the central nucleus of the amygdala (CeA), and the hindbrain (AP/NTS) 10,12,21,44

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Conrad J, Pawlowski M, Dogan M, Kovac St et al (2024) Seizures after cerebrovascular events: Risk factors and clinical features vol 22, pp 275282 Mancuso M, Arnold M, Bersano A, Burlina A, Chabriat H et al (2020) Monogenic cerebral small-vessel diseases: diagnosis and therapy

In most cases, these effects are mild to moderate and tend to improve as the body adapts

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