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Brning A et al

Historical Background and Scientific Context Scientific interest in synthetic peptides expanded substantially as advances in analytical chemistry and peptide synthesis enabled researchers to investigate increasingly complex molecular communication systems

A few select patients have reported they felt their results lasted as long as 2 years

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Animal studies suggest high tolerance and no significant toxicity, even at large doses [44]

Cardiovascular outcome trials evaluating novel agents that target multiple pathways including combinations of GLP-1 agonism, GIP agonism, glucagon receptor agonism and amylin analogues are ongoing and will help define the next generation of obesity treatments